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What is the use of bendamustine?
Bendamustine injection is used to treat chronic lymphocytic leukemia (CLL; a type of cancer of the white blood cells).
Country Of Origin : India
Bendamustine Hydrochloride 100mg, presented by Benrica, is a highly specialized pharmaceutical product used in the therapeutic management of chronic lymphocytic leukemia (CLL). This medicine is essential for oncology treatment plans, featuring an active ingredient known for its efficacy and reliability in targeting specific cancer cells while minimizing damage to healthy cells. Here is a detailed overview of the intricacies and applications of this product.
Bendamustine Hydrochloride is a chemotherapy medication formulated to treat chronic lymphocytic leukemia (CLL), a malignancy affecting the white blood cells. It primarily functions by disrupting the growth of cancerous cells, thereby reducing their proliferation and spread in the body. Clinical research supports its utility in the treatment of CLL due to its ability to bind and alkylate DNA, which leads to the cessation of cancer cell division.
Bendamustine Hydrochloride is prescribed for: - Chronic Lymphocytic Leukemia (CLL) - Non-Hodgkin's Lymphoma (NHL), especially in cases where the disease is slow-growing and the patient has not responded to other treatments.
Bendamustine's mechanism of action involves two primary pathways: 1. Alkylation: Bendamustine functions as an alkylating agent, attaching an alkyl group to the DNA molecule. This action modifies the DNA structure, leading to breaks and mispairing of the DNA strands. Such structural changes inhibit the cancer cells' ability to divide and proliferate. 2. Apoptosis Induction: Besides damaging DNA, bendamustine also induces programmed cell death (apoptosis) in cancer cells. This dual mechanism ensures that the malignant cells are effectively targeted and eradicated, paving the way for reductions in tumor size and the spread of cancer.
Each vial contains: - 100mg bendamustine hydrochloride as the active ingredient. - Excipients that aid in the formulation, stability, and administration of the active ingredient.
The dosage prescribed would typically depend on multiple factors, including the specific type of cancer, the stage of the disease, patient’s body surface area, overall health, and response to treatment. Healthcare providers follow established protocols to determine the appropriate dosage.
Bendamustine is administered intravenously, meaning it is injected directly into the bloodstream by a healthcare professional. The preparation involves reconstituting the powder with a designated solvent to create a solution that can be infused. Guidelines for preparation, handling, and infusion are stringent to maintain the medicine's effectiveness and ensure patient safety.
Understanding the pharmacokinetics of bendamustine provides insight into how the drug is absorbed, distributed, metabolized, and excreted from the body.
Like other potent chemotherapy agents, bendamustine hydrochloride carries the risk of side effects. Patients should be closely monitored for adverse reactions, and symptom management should be part of the treatment plan. Common side effects include:
