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Curcumin is the major bioactive component of the spice herb turmeric or Curcuma longa L., a widely used natural food product in curry powder. Curcumin are limited by its poor solubility, low absorption from the gut, rapid metabolism and rapid systemic elimination. While the major portion of ingested curcumin is excreted through the feces unmetabolized, the small portion absorbed is extensively converted to its water-soluble metabolites, glucuronides and sulfates.
The solubility of Curcumin 95% is relatively very poor and the invivo absorption and bioavailability is subsequently very minimal. Hence large amounts of Curcumin must be taken orally, to have some systemic effects.
BioSOLVE CurcuminTM is dispersible & Bioavailable Curcumin powder from Curcumin 95% (Curcuma Longa) manufactured and supplied by ZeusHygia Lifesciences.
Curcumin, the golden phenolic compound extracted from the roots of the turmeric plant (Curcuma longa L.), has garnered much attention over the years for its potent anti-inflammatory, antioxidant, and potential therapeutic properties. Playing a significant role as the primary bioactive compound in turmeric, Curcumin is central to many traditional medicine systems, especially in Indian and Chinese cultures. However, its application and benefits in modern medicine have been hindered by several challenges including low solubility, poor absorption, rapid metabolism, and systemic elimination. Enter BioSOLVE Curcumin™, a groundbreaking product from ZeusHygia Lifesciences that addresses these critical issues, offering a dispersible and bioavailable form of Curcumin to maximize its therapeutic potential.
BioSOLVE Curcumin™ is a proprietary curcumin formulation enriched with Curcumin 95% extracted from Curcuma longa. This product is meticulously designed to combat the inherent challenges associated with curcumin’s bioavailability, ensuring that the body can reap the myriad benefits of this powerful compound.
Typical curcumin, even at 95% purity, presents a substantial challenge due to its hydrophobic nature. This characteristic limits its solubility in water, a significant barrier given that water solubility is essential for effective gastrointestinal absorption.
Once ingested, curcumin must cross the intestinal barrier to enter systemic circulation. Traditional curcumin’s low solubility translates into minimal absorption through the gut’s epithelial cells. Most of the curcumin consumed in common forms is excreted unchanged in the feces, demonstrating minimal systemic availability.
Any small quantity of curcumin that is absorbed is swiftly metabolized in the liver to form curcumin glucuronides and sulfates, water-soluble metabolites which, while beneficial to some extent, are less effective than curcumin itself. This rapid conversion reduces the amount of free curcumin available in the bloodstream necessary for therapeutic effects.
Curcumin undergoes rapid systemic elimination, translating to a short half-life. This property necessitates frequent dosing to maintain therapeutic levels in the body—a practical challenge for consistent and regulated intake.
Understanding and addressing these challenges, ZeusHygia Lifesciences developed BioSOLVE Curcumin™ to revolutionize curcumin supplementation.
To enhance curcumin’s solubility and absorption, BioSOLVE Curcumin™ is engineered through a meticulous process involving particle size reduction, complexation with dispersing agents, and incorporation into hydrophilic matrices. These technological advancements result in a product that is not only easily dispersible but also remarkably bioavailable.
The enhanced dispersibility of BioSOLVE Curcumin™ ensures that it's broken down into microscopic particles that can be more readily absorbed through the gut lining. This enhanced absorption results in higher plasma concentrations of curcumin, maximizing its therapeutic potential.
BioSOLVE Curcumin’s formulation allows for a more sustained release of curcumin into the bloodstream, addressing the challenge of rapid metabolism and elimination. This sustained release ensures prolonged therapeutic levels, reducing the need for frequent dosing and improving user compliance.
Due to its potent biological activities, curcumin offers a wide range of health benefits. BioSOLVE Curcumin™, with its superior bioavailability, amplifies these benefits:
Curcumin is renowned for its powerful anti-inflammatory properties. It inhibits key molecules in the inflammatory pathway, such as NF-kB and cyclooxygenase-2 (COX-2), which play a crucial role in chronic inflammation. Enhanced bioavailability ensures that effective concentrations
