FPN Tablet

Advance Information*

Introduction to FPN Tablet

FPN Tablet is a combination medication primarily utilized for its potent analgesic and anti-inflammatory properties. Formulated with Aceclofenac and Paracetamol, this tablet offers dual-action relief from pain and inflammation, making it a go-to option for managing various conditions effectively and efficiently. Whether it’s for acute pain management, chronic pain conditions, or inflammation reduction, the FPN Tablet is designed to deliver sustained relief and enhanced patient comfort.

Composition and Key Ingredients

Each film-coated FPN Tablet is meticulously crafted to ensure optimal efficacy and safety. The key active ingredients include:

Aceclofenac IP 100 mg
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) known for its potent anti-inflammatory, analgesic, and antipyretic effects. It is widely used in the treatment of conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Paracetamol IP 325 mg
Paracetamol, also known as acetaminophen, is a widely-recognized analgesic and antipyretic agent. It is effective in reducing fever and relieving mild to moderate pain. The combination of Paracetamol with Aceclofenac enhances the overall efficacy of FPN Tablet by providing rapid relief from pain and inflammation.

Mechanism of Action

Aceclofenac

Aceclofenac works by inhibiting the enzyme cyclooxygenase (COX), which plays a crucial role in the synthesis of prostaglandins. Prostaglandins are lipid compounds that mediate inflammation and pain. By reducing the production of these compounds, Aceclofenac effectively alleviates symptoms associated with inflammatory conditions.

Paracetamol

Paracetamol exerts its action primarily on the central nervous system, where it inhibits the COX enzyme activity. This, in turn, reduces the synthesis of prostaglandins in the brain, leading to reduced perception of pain and lowered fever.

Indications and Usage

FPN Tablet is indicated for use in a variety of conditions where pain and inflammation are present. Some of the common indications include:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Chronic and acute musculoskeletal disorders
• Post-operative pain
• Dysmenorrhea
• Headaches and Dental pain

Benefits of FPN Tablet

The unique combination of Aceclofenac and Paracetamol in the FPN Tablet offers several benefits, including:

1. Synergistic Effect: The combination of two active compounds works synergistically to enhance overall efficacy, providing faster and more sustained relief from symptoms.
2. Broad Spectrum of Action: Effective against a wide range of pain and inflammation-related conditions, ensuring versatile usage.
3. Improved Patient Compliance: Easier to use compared to taking two separate medications, improving compliance rates among patients.
4. Film-coated Design: Ensures the tablet is easy to swallow and reduces the risk of gastrointestinal discomfort associated with NSAIDs.

Dosage and Administration

Adults and Elderly
The recommended dosage of the FPN Tablet for adults and elderly patients is typically one tablet taken twice daily. The dosage can be adjusted based on the severity of the condition and the patient’s response to the treatment.

Pediatric
The FPN Tablet is generally not recommended for use in children unless prescribed by a healthcare professional.

Pharmacokinetics

Aceclofenac
- Absorption: Aceclofenac is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations generally achieved 1-3 hours post-administration. - Distribution: It is extensively bound to plasma proteins, facilitating widespread distribution throughout the body. - Metabolism: Primarily metabolized in the liver. - Excretion: It is excreted via the kidneys, with a half-life of approximately 4 hours.

Paracetamol
- Absorption: Paracetamol is readily absorbed from the gastrointestinal tract, typically reaching peak plasma concentrations within 30-60 minutes. - Distribution: It is widely distributed in the body fluids and tissues. - Metabolism: Undergoes hepatic metabolism. - Excretion: Primarily excreted in the urine, with a half-life of approximately 2-3 hours.

Side Effects

As with any medication, the FPN Tablet may cause side effects in some patients. Common side effects include:

• Gastrointestinal disturbances (nausea, vomiting, indigestion)
• Dizziness or headache
• Rash or allergic reactions
• Hepatic dysfunction (rare)

It is important to consult a healthcare professional if any of these side effects persist or worsen.

Precautions and Warnings

1. Gastrointestinal Risks: Patients with a history of gastrointestinal ulcers, bleeding, or