Amoxycillin and Potassium Clavulanate tablet

Advance Information*

Product Overview

The S-Clave 625 Tablet is a potent combination medicine that effectively addresses various types of bacterial infections. This prescription medicine combines Amoxycillin, a penicillin-type antibiotic, with Potassium Clavulanate, a beta-lactamase inhibitor, to enhance the antibiotic's efficacy. Amoxycillin fights against bacteria by interfering with their cell wall synthesis, ultimately leading to bacterial cell death. Potassium Clavulanate, on the other hand, helps in overcoming resistance by inhibiting the beta-lactamase enzymes produced by some bacteria, making the antibiotic more effective.

Indications

S-Clave 625 Tablet is primarily prescribed for:

• Respiratory tract infections such as bronchitis, pneumonia, sinusitis, and pharyngitis.
• Skin and soft tissue infections.
• Urinary tract infections.
• Dental infections such as abscesses.
• Ear infections like otitis media.

Dosage and Administration

S-Clave 625 Tablet should be taken exactly as prescribed by a healthcare professional. Typical guidelines include:

• Adults and children over 12 years: One tablet taken every 8-12 hours, depending on the severity and type of infection.
• Children below 12 years: Dose adjustments are made based on weight and infection severity, always follow the pediatrician's instructions.

The tablet can be taken with or without food, but it is advisable to take it at a fixed time each day for optimal results. Swallow the tablet whole with a glass of water; do not crush or chew the tablet.

Mechanism of Action

• Amoxycillin: Disrupts the synthesis of the bacterial cell wall leading to lysis and death of the bacterial cell.
• Potassium Clavulanate: Inhibits beta-lactamase enzymes protecting amoxycillin from degradation by these enzymes, thus extending its spectrum of activity.

Pharmacokinetics

• Absorption: Rapidly absorbed from the gastrointestinal tract with peak plasma concentrations observed within 1 to 2 hours after administration.
• Distribution: Distributes widely in body tissues and fluids including the lungs, liver, bones, and synovial fluids.
• Metabolism: Partially metabolized in the liver.
• Excretion: Primarily excreted unchanged in the urine.

Side Effects

While S-Clave 625 Tablet is generally well tolerated, some individuals may experience side effects. Common side effects include:

• Gastrointestinal: Nausea, vomiting, diarrhea, indigestion, abdominal pain.
• Hematologic: Rarely, it may cause a decrease in blood cells.
• Allergic Reactions: Rashes, itching, swelling, and in severe cases, shortness of breath. Immediate medical attention is required.
• Liver: Transient increases in liver enzymes.

Should any side effects become severe or persistent, it is important to consult a healthcare provider.

Precautions and Warnings

• Allergies: Inform your doctor if you have had an allergic reaction to penicillin antibiotics or any other allergies.
• Pregnancy and Breastfeeding: Consult your doctor before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.
• Liver/Kidney Impairment: Use with caution and under medical supervision if you have liver or kidney conditions.
• Drug Interactions: Inform your doctor about all medicines you are taking, including over-the-counter drugs, to avoid potential interactions.

Contraindications

Do not use S-Clave 625 Tablet if you have:

• A known hypersensitivity to amoxycillin, clavulanate, or any other beta-lactam antibiotics.
• A history of liver dysfunction associated with the use of amoxycillin/clavulanate potassium.

Drug Interactions

Potential drug interactions include:

• Oral Anticoagulants: May increase the risk of bleeding.
• Methotrexate: Enhanced risk of methotrexate toxicity.
• Probenecid: Can increase the level of amoxycillin by inhibiting its renal excretion.
• Allopurinol: Concurrent use may increase the likelihood of skin rash.

Always consult your healthcare provider or pharmacist before starting any new medications.

Overdose

Symptoms of overdose may include severe diarrhea, vomiting, or seizures. In the event of an overdose, seek immediate medical attention. Treatment is largely supportive and includes monitoring electrolytes and maintaining adequate hydration.

Storage

Keep the medication in its original packaging until it is time to take it. Store it at room temperature, away from direct light and moisture. Ensure that it is kept out of the reach of children to prevent accidental ingestion.

Laboratory and Diagnostic Tests

Your healthcare provider may recommend periodic blood tests, liver function tests,